Due to its low risk, high accuracy, and deep penetration into tissue, Ultrasound (US) has become one of the most widely used methods in the diagnosis and treatment of disease. US is gaining more attention in the Drug/gene Delivery Systems (DDS) due to the countless benefits it offers in relations of site-precise delivery as well as spatial statementdelivery of medications/genetic factor. The most popular type of ultrasound-responsive delivery material is Microbubbles (MBs). Nanobubbles, droplets, micelles, as well as nanoliposomes are just some of the recent innovations in this area that serve as carriers. In order to encourage further research into ultrasound approachable materials as distributioncarters, we review recent successes with novel ultrasound receptive materials (Microbubbles (MBs), Micelles, Liposomes and Niosomes) and deliberate the challenges associated with using Ultrasound-Responsive Materials (US-RM) in Drug Delivery Systems (DDS).
Keywords
Drug Delivery Systems (DDS), Ultrasound (US), Ultrasound-Responsive Materials (US-RM), Microbubbles (MBs)
D. Fu et al., “A novel redox-responsive ursolic acid polymeric prodrug delivery system for osteosarcoma therapy,” Drug Deliv., vol. 28, no. 1, pp. 195–205, 2021.
C. A. Franco-Urquijo, J. Á. Navarro-Becerra, A. Ríos, and B. Escalante, “Release of vascular agonists from liposome-microbubble conjugate by ultrasound-mediated microbubble destruction: effect on vascular function,” Drug Deliv. Transl. Res., vol. 12, no. 5, pp. 1175–1186, 2022.
H. Chen, D. Evangelou, K. Loskutova, M. Ghorbani, and D. Grishenkov, “On the development of a novel contrast pulse sequence for polymer-shelled microbubbles,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 68, no. 5, pp. 1569–1579, 2021.
R. A. Barmin et al., “Engineering the acoustic response and drug loading capacity of PBCA-based polymeric microbubbles with surfactants,” Mol. Pharm., vol. 19, no. 9, pp. 3256–3266, 2022.
S. M. Haftcheshmeh et al., “Liposomal doxorubicin targeting mitochondria: A novel formulation to enhance anti-tumor effects of Doxil® in vitro and in vivo,” J. Drug Deliv. Sci. Technol., vol. 62, no. 102351, p. 102351, 2021.
S. Dikalov, T. Losik, and J. L. Arbiser, “Honokiol is a potent scavenger of superoxide and peroxyl radicals,” Biochem. Pharmacol., vol. 76, no. 5, pp. 589–596, 2008.
A.-K. Diesch and S. Grissmer, “Kinetic aspects of verapamil binding (on-rate) on wild-type and six hKv1.3 mutant channels,” Cell. Physiol. Biochem., vol. 44, no. 1, pp. 172–184, 2017.
C.-Y. Tsai, L.-W. Teng, M.-C. Chang, Y.-P. Tseng, and L. I, “Solitary wake field microdynamics of the pulsed laser induced microbubbles in three-dimensional dusty plasma liquids,” Phys. Plasmas, vol. 16, no. 6, p. 063702, 2009.
J. Shen et al., “Overexpression of PYGO1 promotes early cardiac lineage development in human umbilical cord mesenchymal stromal/stem cells by activating the Wnt/β-catenin pathway,” Hum. Cell, vol. 35, no. 6, pp. 1722–1735, 2022.
C. O. Rees et al., “OP06.01: Quantitative ultrasound measurement of endometrial waves in adenomyosis versus women with normal uteri: the WAVES study,” Ultrasound Obstet. Gynecol., vol. 60, no. S1, pp. 64–64, 2022.
H. Mehrad, “Effect of HDL- loaded pesda microbubbles- mediated focused shock wave sonoporation therapy on biomechanical parameters in an experimental animal model of abdominal aorta fibroatheromatic plaque,” Atherosclerosis, vol. 355, p. 244, 2022.
Y. Xia et al., “Corrigendum to ‘Enhancement of flotation response of fine low-rank coal using positively charged microbubbles’ [Fuel 245 (2019) 505–513],” Fuel (Lond.), vol. 250, p. 381, 2019.
G. Tzvetkov, P. Fernandes, S. Wenzel, A. Fery, G. Paradossi, and R. H. Fink, “Soft X-ray induced modifications of PVA-based microbubbles in aqueous environment: a microspectroscopy study,” Phys. Chem. Chem. Phys., vol. 11, no. 7, pp. 1098–1104, 2009.
T. Liu and M. Lang, “Preparation and characterization of novel functional tri-block copolymer for constructing temperature/redox dual-stimuli responsive micelles,” J. Macromol. Sci. Part A Pure Appl. Chem., vol. 59, no. 8, pp. 513–525, 2022.
A. Baldelli et al., “Engineered nasal dry powder for the encapsulation of bioactive compounds,” Drug Discov. Today, vol. 27, no. 8, pp. 2300–2308, 2022.
S. Motamedi, B. Massoumi, M. Jaymand, H. Derakhshankhah, and E. Alizadeh, “Bioreducible and pH-responsive shell crosslinked polymeric micelles from a star-shaped terpolymer as drug delivery system,” Int. J. Polym. Mater., vol. 71, no. 7, pp. 481–492, 2022.
B. O’Neill and C. Li, “Translational studies of the effects of pulsed HIFU using a modified clinical MR guided focused ultrasound device,” FocUS Archive, 2018.
Y. Horise et al., “Sonodynamic therapy with anticancer micelles and high-intensity focused ultrasound in treatment of canine cancer,” Front. Pharmacol., vol. 10, p. 545, 2019.
H.-Y. Chen, M. Hsu, and C.-W. J. Lio, “Micro but mighty-Micronutrients in the epigenetic regulation of adaptive immune responses,” Immunol. Rev., vol. 305, no. 1, pp. 152–164, 2022.
M. Zhang et al., “Application value of contrast-enhanced ultrasonography in the treatment of uterine fibroids by high-intensity focused ultrasound ablation: A retrospective study,” J. Clin. Ultrasound, 2022.
Zhao Y., Guo J., Tang H., and Bao X., “Intratympanic methylprednisolone hemisuccinate injection in treating the refractory noise induced deafness,” Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, vol. 33, no. 7, pp. 547–548, 2015.
E. R. Gomes et al., “Fusion of tumor-derived exosomes with long-circulating and pH-sensitive liposomes loaded with doxorubicin for the treatment of breast cancer,” AAPS PharmSciTech, vol. 23, no. 7, p. 255, 2022.
I. Lentacker, B. Geers, J. Demeester, S. C. De Smedt, and N. N. Sanders, “Tumor cell killing efficiency of doxorubicin loaded microbubbles after ultrasound exposure,” J. Control. Release, vol. 148, no. 1, pp. e113-4, 2010.
C. Thedrattanawong, C. Thanapongpibul, P. Nittayacharn, and N. Nasongkla, “Reduction the initial-burst release of Doxorubicin from polymeric depot as a local drug delivery system for cancer treatment,” Annu Int Conf IEEE Eng Med Biol Soc, vol. 2018, pp. 4221–4224, 2018.
H. Wang et al., “Application of ultrasonication at different microbial growth stages during apple juice fermentation by Lactobacillus plantarum: Investigation on the metabolic response,” Ultrason. Sonochem., vol. 73, no. 105486, p. 105486, 2021.
W. Qiang and K. E. Doherty, “Model phospholipid liposomes to study the β-amyloid-peptide-induced membrane disruption,” Methods Mol. Biol., vol. 1777, pp. 355–367, 2018.
C. J. Thébault et al., “In vivo evaluation of magnetic targeting in mice colon tumors with ultra-magnetic liposomes monitored by MRI,” Mol. Imaging Biol., vol. 21, no. 2, pp. 269–278, 2019.
R. Chandan and R. Banerjee, “Pro-apoptotic liposomes-nanobubble conjugate synergistic with paclitaxel: a platform for ultrasound responsive image-guided drug delivery,” Sci. Rep., vol. 8, no. 1, 2018.
T. Yin et al., “Tumor-penetrating codelivery of siRNA and paclitaxel with ultrasound-responsive nanobubbles hetero-assembled from polymeric micelles and liposomes,” Biomaterials, vol. 35, no. 22, pp. 5932–5943, 2014.
H. Ding et al., “A novel nano material for anti-cerebral ischaemia: preparation and application of borneol angelica polysaccharide liposomes,” J. Liposome Res., pp. 1–10, 2022.
C. Chen et al., “Method for loading liposomes with soybean protein isolate hydrolysate influences the antioxidant efficiency of liposomal systems: Adding after liposomes formation or before lipid film hydration,” Food Hydrocoll., vol. 129, no. 107629, p. 107629, 2022.
J. Leelarungrayub, J. Manorsoi, and A. Manorsoi, “Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunarRoxb.) by therapeutic ultrasound in a rat model,” Int. J. Nanomedicine, vol. 12, pp. 2469–2476, 2017.
P. Shinu et al., “Recent advances and appropriate use of niosomes for the treatment of skin cancer,” Ind. J. Pharm. Educ., vol. 56, no. 4, 2022.
T. Lu and T. L. M. Ten Hagen, “A novel kinetic model to describe the ultra-fast triggered release of thermosensitive liposomal drug delivery systems,” J. Control. Release, vol. 324, pp. 669–678, 2020.
P.-C. Chu, H.-Y. Yu, C.-C. Lee, R. Fisher, and H.-L. Liu, “Pulsed-focused ultrasound provides long-term suppression of epileptiform bursts in the kainic acid-induced epilepsy rat model,” Neurotherapeutics, 2022.
Acknowledgements
Author(s) thanks to Dr. Emily Girma for this research validation and verification support.
Funding
No funding was received to assist with the preparation of this manuscript.
Ethics declarations
Conflict of interest
The authors have no conflicts of interest to declare that are relevant to the content of this article.
Availability of data and materials
No data available for above study.
Author information
Contributions
All authors have equal contribution in the paper and all authors have read and agreed to the published version of the manuscript.
Corresponding author
Crystal Dunn
Crystal Dunn
Faculty of Medicine and Health Sciences, Columbus University, 3a Oeste, David, Panama.
Open Access This article is licensed under a Creative Commons Attribution NoDerivs is a more restrictive license. It allows you to redistribute the material commercially or non-commercially but the user cannot make any changes whatsoever to the original, i.e. no derivatives of the original work. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
Cite this article
Emily Girma and Crystal Dunn, “Ultrasound-Responsive Materials for Drug/Gene Delivery”, Journal of Biomedical and Sustainable Healthcare Applications, vol.2, no.2, pp. 101-112, July 2022. doi: 10.53759/0088/JBSHA202202012.