Biomanufacturing utilizes biological systems for the production of medical products and therapies, biomaterials, food & beverages, and specialty chemicals. Startups are advancing different cell culture, fermentation, and recombinant production technologies to make biomanufacturing inexpensive and scalable. The use of biological raw materials also makes it comparatively more sustainable as compared to other manufacturing paradigms. The industry’s production models are also adopting machine learning and automation. By integrating Industry 4.0 models, Biotechnology startups offer bioprocessing 4.0 to optimize each step of the production process.[1]

Figure 1. Biomanufacturing

Biomanufacturing is shown in figure 1. Biomanufacturing technicians clean and sanitize equipment in medical and industrial settings such as the manufacture of pharmaceuticals, cosmetics, and other materials. They utilize their knowledge of standard practices and operating procedures as well as critical thinking, good communication, and teamwork.[2]

Benefits of biomanufacturing

• Energy use reduction
• Increased innovation
• Sustainability

Biomanufacturing process details

Some of the processes in which biomanufacturing can be involved are as follows:

• Raw material production, including plastics, paper and textiles
• Chemical production, using fermentation to develop soaps, detergents and more
• Energy production, generating power from biomass
• Food fortification and enhancement through natural processes as opposed to additives and preservatives [3]

Immobilized multienzyme systems are gaining momentum in chemical biomanufacturing due the extraordinary advances in material sciences combined with tools that allow to tune the interactions between both protein and solid surfaces. This chapter highlights the most important parameters to be controlled in order to maximize the performance of multienzyme systems immobilized on solid materials. The examples given here, illustrate how the nature and the physicochemical properties of solid carriers impact the functionality (activity, selectivity, and stability) of the immobilized enzymes. Unfortunately, the fabrication of multifunctional heterogeneous biocatalyst based on the precise coimmobilization of multienzyme system is not a trivial task.[4]

References:

1. https://www.startus-insights.com/innovators-guide/top-10-biotech-industry-trends-innovations-in-2021/
2. https://www.calstatela.edu/page/biomanufacturing-technician-certificate-program
3. https://www.advancedtech.com/blog/future-of-biology-in-manufacturing/
4. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/biomanufacturing

Cite this article:

Gokula Nandhini K (2023), Biomanufacturing, Anatechmaz, pp.116