Researchers at the CNIC as well as Medical Facility Universitario Puerta de Hierro in Majadahonda have actually established a software program application that forecasts the chance that an instance of dilated cardiomyopathy is triggered by a hereditary anomaly. The research study was executed in cooperation with health centers in Spain, Italy, as well as the Netherlands.The software application is available online at www.madriddcmscore.com.

Figure 1: A software application to determine dilated cardiomyopathy has a genetic origin.

Figure 1 shows thatDilated cardiomyopathy is one of the most constant sources of cardiac arrest in youths as well as the major indicator for heart transplant on the planet. The illness is defined by augmentation of the heart come with by a decrease in its ability to pump blood, as well as clients with this problem go to high danger of arrhythmias as well as abrupt heart fatality. [1]

In approximately 30% of patients with dilated cardiomyopathy, the disease arises as a consequence of a heritable genetic mutation. Knowing that a patient’s disease has a genetic cause allows physicians to adjust treatment appropriately and to identify other family members who have also inherited the disease.

The new study was led by cardiologist Dr. Pablo García-Pavía of Hospital Puerta de Hierro, and who is also a research scientist at the CNIC and in the Spanish cardiovascular research network (CIBERCV).

The study analyzed the clinical characteristics, electrocardiograms, and echocardiography data of a group of 1015 dilated cardiomyopathy patients who underwent genetic screening at 20 Spanish hospitals.The results identified 5 parameters that were more frequent in patients in whom the disease was caused by a genetic mutation. [2]

The combined scoring of these five parameters in a software application, called the Madrid Genotype Score, allows the classification of patients according to the likelihood that their disease has an origin in a heritable genetic mutation.

Dr. Luis Escobar explained that "among patients positive for most of these parameters, the disease was more likely to have a genetic cause, whereas among patients negative for the parameters or positive for only one or two, the probability was lower. A genetic cause was found in only 2% of patients negative for all five parameters."

The researcher team verified the predictive ability of the tool in an independent group of 1,097 dilated cardiomyopathy patients from Italy and the Netherlands. [3]

References:

1. https://newspostalk.com/genetics/scientists-develop-a-tool-to-determine-if-dilated-cardiomyopathy-has-a-genetic-origin/
2. https://bioengineer.org/scientists-at-the-cnic-and-hospital-puerta-de-hierro-develop-a-tool-to-determine-if-dilated-cardiomyopathy-has-a-genetic-origin/
3. https://medicalxpress.com/news/2022-09-scientists-tool-dilated-cardiomyopathy-genetic.html

Cite this article:

Sri Vasagi K (2022), New Tool to Determine Dilated Cardiomyopathy has a Genetic Origin, AnaTechMaz, pp.109