Marking a significant breakthrough in research for the treatment of cancer, scientists have developed a compound that may kill some difficult-to-treat cancer types. The findings are part of a new study recently published natural science, The new compound targets a vulnerability that was not previously discovered by the researchers. According to study leader and professor of obstetrics and gynecology at UT Health Center in San Antonio, Ratna Vadlamudi, PhD, the scientists identified a critical vulnerability in several cancers and validated the findings in several cancer cell types and animal models. [1]

Figure 1. Scientists Develop New Compound that may help Fight Elusive Cancer Types

Figure 1 shows the ERX-11 compound targets the estrogen receptor (ER), which is behind most of the breast cancers.

The ERX-11 compound targets the estrogen receptor (ER), which is the leading cause behind most of the breast cancers. After the compound was identified, scientists scanned through a screen of chemical analogs of ERX-11 and observed that another compound named ERX-41 was effective in killing ER-positive cancers in petri dishes. It was also found that the compound managed to eliminate triple-negative breast cancers (TNBCs). The finding was significant as there is a lack of targeted treatments for TNBC due to the absence of progesterone, estrogen, and human epidermal growth factor 2 in it. [2]

Casting the net wider, scientists, using mouse models, highlighted that ERX-41 also showed activity against a large number of human tumours. It was learned that the compound effectively shrunk the tumours in mouse models without resulting in toxicity in the animals or affecting normal breast cells.

In addition, ERX-41 proved to be working against other cancer types with elevated endoplasmic reticulum stress. These include cancers that don’t have many effective treatments for them like ovarian cancers, glioblastoma, and pancreatic cancers. [3]

References:

1. https://news.bharattimes.co.in/this-new-compound-may-help-fight-elusive-cancer-types/
2. https://gadgets360.com/science/news/scientists-develop-compound-help-fight-elusive-cancer-types-3035429
3. https://newzflash.in/scientists-develop-new-compound-that-may-help-fight-elusive-cancer-types/
4. https://www.technologyshout.com/scientists-develop-new-compound-that-may-help-fight-elusive-cancer-type/

Cite this article:

Thanusri swetha J (2022), Scientists Develop New Compound that may help Fight Elusive Cancer Types, Anatechmaz, pp. 69