“We previously identified COX7RP as a mitochondrial protein that plays a central role in promoting the formation of respiratory supercomplexes, which boost cellular energy production while lowering reactive oxygen species (ROS) responsible for oxidative stress,” explains Dr. Inoue. “Building on this discovery, we set out to examine how COX7RP and mitochondrial respiratory supercomplexes influence aging and anti-aging mechanisms.”

Figure 1. Scientists Identify a Protein Linked to Longer Life.

To do so, the research team created COX7RP-transgenic (COX7RP-Tg) mice that were genetically engineered to produce elevated levels of COX7RP throughout their lifespan. This model allowed the researchers to closely assess the protein’s effects on longevity, aging processes, and metabolic health. Figure 1 shows Scientists Identify a Protein Linked to Longer Life.

Longer Lifespan and Improved Metabolism

The results were striking. COX7RP-Tg mice lived significantly longer, with an average lifespan increase of 6.6% compared to wild-type mice. Beyond living longer, these mice also showed clear signs of improved healthspan. They exhibited better glucose regulation due to enhanced insulin sensitivity, healthier lipid metabolism with lower triglyceride and total cholesterol levels, increased muscle endurance, and reduced fat accumulation in the liver.

At the cellular level, COX7RP markedly enhanced mitochondrial efficiency. Tissues from the transgenic mice showed increased formation of mitochondrial respiratory supercomplexes, resulting in higher ATP production.

Further analysis of white adipose tissue revealed improvements in several aging-related markers, including elevated levels of coenzyme NAD+ and reduced levels of ROS and the senescence marker β-galactosidase. Single-nucleus RNA sequencing of white adipose tissue from older mice also showed decreased expression of genes associated with age-related inflammation, particularly those linked to the senescence-associated secretory phenotype (SASP), a hallmark of senescent cells.

Implications for Anti-Aging Approaches

Taken together, these findings indicate that enhancing mitochondrial energy efficiency may help delay aging and reduce age-related decline.

“Our study uncovers new mitochondrial mechanisms that contribute to longevity and healthy aging, offering fresh perspectives on strategies to extend healthspan and lifespan,” says Dr. Inoue. “For example, supplements or therapies that promote the assembly and function of mitochondrial respiratory supercomplexes could potentially support longevity.”

Future research may establish mitochondrial supercomplexes as promising therapeutic targets, opening the door to new interventions aimed at preserving vitality and combating age-related metabolic disorders such as diabetes, dyslipidemia, and obesity.

Source: SciTECHDaily

Cite this article:

Priyadharshini S (2025), New Research Points to a Protein That Could Unlock the Secret to Longevity, AnaTechMaz, pp.1239